Image of Analysis of Flow Characteristics and Paracetamol Tablet Hardness Using 2D Double Mixer of Design Drum Type with Rotation and Mixing Time Variations

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Analysis of Flow Characteristics and Paracetamol Tablet Hardness Using 2D Double Mixer of Design Drum Type with Rotation and Mixing Time Variations

Abstract – Font 11
One of the tablet manufacturing processes using the wet granulation method is the process of
mixing the active ingredient granules, fillers, binders and pelicans. The parameters of the mixing
process are important to study because they will affect the physical properties of the tablet. This
study studied the effect of the variable duration and the size of the mixing cycle on the physical
properties of paracetamol tablets using a 2D double mixer. The results of the analysis and testing
showed that the variation of mixing time and the size of the rotation had a significant effect on the
flow properties of the granules and the hardness of the tablets. In addition, the optimal parameter
results to obtain optimal tablet hardness occurred at 15 minutes of mixing process and 50 rpm of
rotation.
Keywords: mixer-2D, drum, flow properties, tablet hardness, paracetamol

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Detail Information
Series Title
-
Call Number
621.8
Publisher
Surabaya : Institut Teknologi Adhi Tama Surabaya.,
Collation
-
Language
English
ISBN/ISSN
2776-3536
Classification
621.8
Content Type
-
Media Type
-
Carrier Type
-
Edition
-
Subject(s)
mesin otomotif
teknik mesin
Specific Detail Info
-
Statement of Responsibility
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No other version available

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